We are experiencing exceptionally high volumes in our emergency rooms.
Every patient is important to us, and we are doing all we can to provide care quickly and efficiently.
Skip to main content
Go to homepage

Print Page

Hydroxyurea for People With Sickle Cell Disease

What Is Hydroxyurea?

Hydroxyurea is a medicine that can help people who have sickle cell disease. It keeps blood cells round and flexible, so they flow better and deliver oxygen to the body more easily. This means less pain and fewer trips to the hospital.

What Happens in Sickle Cell Disease?

Sickle cell disease makes red blood cells become C-shaped instead of round. These sickle-shaped cells get stuck and block the blood flowing inside small blood vessels. This can be painful. It can lead to other problems that need to be treated in the hospital.

Sickle cells also break down more quickly than healthy red blood cells. Having too few red blood cells can lead to anemia. People with anemia feel tired and have less energy.

How Does Hydroxyurea Help People With Sickle Cell Disease?

Hydroxyurea (hy-drok-see-yer-EE-uh) helps the body make a type of hemoglobin that helps keep red blood cells round. Hemoglobin is the protein inside red blood cells that carries oxygen to the body. Round and flexible red blood cells work better and last longer. So people who take hydroxyurea can have more energy, and less pain and anemia. They often spend less time in the hospital.

Who Can Take Hydroxyurea?

Hydroxyurea can help people with sickle cell disease, including those who have:

  • some types of sickle cell disease (like the most common type, called hemoglobin SS)
  • lots of pain crises (some people get these often, but others don’t)
  • acute chest syndrome
  • severe anemia needing blood transfusions
  • tiny blockages without any pain. Sickle cells can scrape the inside of blood vessels. This creates small places for blood cells to get stuck and form a blockage. A blockage that stays small might not cause pain, but it can still prevent blood and oxygen from getting where they need to go.

Children as young as 9 months old can take hydroxyurea.

Doctors sometimes use hydroxyurea to treat other kinds of health problems, not just sickle cell disease. Like many medicines, it has different uses. In high doses, it can help with some kinds of blood cancers. The dose used to treat sickle cell disease is very low.

How Do Children Take Hydroxyurea?

Hydroxyurea comes as either a liquid medicine or a small capsule that your child or teen swallows one time each day. It works best when they take it at the same time every day. Some people find it helps to set an alarm to stay on schedule.

Before your child starts taking the medicine, your care team will order a blood test to figure out the starting dose. Then they’ll order monthly blood tests to see how the medicine is working. As hydroxyurea boosts a person’s healthy red blood cells, it sometimes can affect other blood cells. Regular blood tests help the care team make sure the dose is right. They can change the dose or stop the medicine, if needed.

It can take a few months to find the right dose. After that, your child will get blood tests less often.

Does Hydroxyurea Cause Side Effects?

Most people who take hydroxyurea do well and don’t notice any side effects. Those who do might have dark fingernails or headaches. Often, side effects go away quickly as a person adjusts to the new medicine.

How Much Does Hydroxyurea Cost?

Hydroxyurea is usually paid for by insurance. Your cost (if any) will depend on the type of insurance you have. Your child's doctor’s office will help you find out if there are costs for you.

To take a balanced look at costs, it helps to compare the planned costs of taking hydroxyurea with the unplanned costs of not taking it. Pain crises and anemia can lead to ER visits, hospital stays, and missed days of work or school. In addition to a person not feeling well, these problems can be expensive.

When deciding what’s best for your child, ask yourself questions like:

  • How much will I pay for hydroxyurea?
  • How much will my child's care cost if they need treatment for a problem from sickle cell disease?

If the care team recommends hydroxyurea for your child, talk to them if you have questions or concerns. If your child is old enough, include them in the discussion too. Together you can make a choice you both can feel good about.

Reviewed by: Corinna L. Schultz, MD
Date Reviewed: Nov 1, 2022

Lea este articulo en Español

What next?

Summit Mall Play Area
Answer Key:
Click to expand
There are 10 nurses in the picture.

And we have many more pediatric primary care providers in Northeast Ohio. You can meet some of them here.
Summit Mall Play Area
Answer Key:
Click to expand
The five differences are:
– Phone color
– Coat pocket
– Stethoscope earpiece color
– Stethoscope bell dot
– Clipboard paper color

Need help finding a doctor, choosing a location or getting a general question about Akron Children's answered? Call us or fill out the form and we'll help in any way we can.
Summit Mall Play Area
Answer Key:
Click to expand
The two matching doctors are 9 and 14.

With virtual visits, you can see our pediatric experts from the comfort of home or wherever you are.
Summit Mall Play Area
Answer Key:
Click to expand
The correct path:
The Correct Path
We offer many ways to get pediatric care all over Northeast Ohio. Use this page to find the right kind of care and the most convenient location for you.