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Cognitive effects of commonly-prescribed antiepileptic drugs in children with new-onset seizures: a prospective longitudinal study

Study of Cognitive effects of antiepileptic drugs in children with new-onset seizures


Epilepsy is the most common neurologic disorder in children affecting 4-6 per 1000 children Antiepileptic drugs (AEDs) are the primary, and frequently exclusive, treatment option for epilepsy. While necessary and effective for seizure control, AEDs can also cause neurotoxicity, adversely affecting functioning of the central nervous system. This study aims to evaluate patients before starting AED’s  to evaluate any possible side effects or difference in the child’s ability to perform certain tasks (cognitive functioning)  The purpose of the proposed study is to examine the cognitive and behavioral effects of commonly prescribed AEDs on children with new onset seizures. This will be accomplished by recruiting children who are seen in the new onset seizure clinic in the Neurology service of the Neuro Developmental Science Center (NDSC) at Akron Children’s Hospital.

Who May Qualify?:

Children that have been diagnosed with new-onset seizures.

Who Does Not Qualify:

Children that have already begun prescribed treatments for their epilepsy. 

Study Status:
Study Sponsor:

Akron Children’s Hospital Foundation

Full IRB Study Title:
Cognitive effects of commonly prescribed antiepileptic drugs in children with new-onset seizures: a prospective longitudinal study
IRB Study ID:
If you are interested in this study or have questions about your child's eligibility, please contact:
Rebecca D. Considine Research Institute, 330-543-3193 or email
Lead Investigator
Dalin Pulsipher, PhD, ABPP

Pediatric Neuropsychologist
Pediatric Brain Tumor ProgramPediatric Neurobehavioral HealthHead Injury ClinicPediatric Epilepsy ProgramNeuroDevelopmental Science CenterLead Clinic