Research - Open Studies
Carefully planned and closely monitored, studies run the gamut in terms of what is required from patients or parents. Some are as simple as asking a parent (or child) to complete a survey. Other studies may require diagnostic tests, entering information in a home diary, or periodic visits to the hospital.
Should you find a study that might help your child, learn as much as possible about the study’s purpose and the activities involved. Find out what you will be asked to do. Write down your questions. The doctor leading the study, or a qualified study team member, will explain the study in detail. If you don’t understand, continue to ask for further explanation.
Contact the Research Institute at 330-543-3193 for more information on a study.
- Safety and Efficacy of Nexium in Pediatric Patients with Erosive Esophagitis Currently recruiting
- IBD ImproveCareNow Registry - working to improve the care and health of children with inflammatory bowel disease Currently recruiting
- A study evaluating the safety and efficacy of Debio 4326 in treating precocious puberty in children receiving gonadotropin-releasing hormone agonist Currently recruiting
- Dupixent in post-burn pruritus Currently recruiting
- A study to compare standard therapy to treat Hodgkin Lymphoma with the use of two drugs, Brentuximab Vedotin and Nivolumab Currently recruiting
- Biomarkers in tumor samples from patients with newly-diagnosed neuroblastoma or ganglioneuroblastoma Currently recruiting
- Dinutuximab with chemotherapy, surgery and stem cell transplantation for the treatment of children with newly-diagnosed high risk neuroblastoma Currently recruiting
- The Project: Every Child Protocol: A Registry, Eligibility Screening, Biology and Outcome Study Currently recruiting
- A study to test the addition of the drug Cabozantinib to chemotherapy in patients with newly diagnosed osteosarcoma Currently recruiting
- Selumetinib vs. Carboplatin and Vincristine in patients with low-grade glioma Currently recruiting
- Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma Currently recruiting
- Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma Currently recruiting
- Maintenance Chemotherapy or Observation Following Induction Chemo and Radiation for Ependymoma Currently recruiting
- Study to determine the safety and tolerability of SNDX-5613 in patients with relapsed/refractory leukemia Currently recruiting
- Genetic Analysis Identifying Late Occurring Complications in Childhood Cancer Survivors (ALTE03N1) Currently recruiting
- A study of a new way to treat children and young adults with a brain tumor called NGGCT Currently recruiting
- A study of treatment for medulloblastoma using sodium thiosulfate to prevent hearing loss Currently recruiting
- Active surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in treating pediatric and adult patients with germ cell tumors Currently recruiting
- Safety and efficacy of Ravulizumab for pediatric patients with thrombocytic microangiopathy following hematopoetic stem cell transplantation Currently recruiting
- Accelerated v’s standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours (P3BEP) Currently recruiting
- A study to compare treatment with Selumetinib alone vs. Selumetinib and Vinblastine in patients with recurrent or progressive low-grade glioma Currently recruiting
- Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma Currently recruiting
- Nivolumab in combination with chemo-immunotherapy for the treatment of newly diagnosed primary mediastinal B-Cell lymphoma Currently recruiting
- Treatment of newly-diagnosed diffuse anaplastic Wilms tumors (SAWT) and relapsed favorable histology Wilms tumors (FHWT)
- Thoracotomy versus thoracoscopic management of pulmonary metastases in patients with osteosarcoma Currently recruiting
- A study using risk factors to determine treatment for children with favorable histology Wilms tumors (FHWT) Currently recruiting
- A study to give treatment inside the eye to treat retinoblastoma Currently recruiting
- A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma Currently recruiting
- Chemotherapy for the treatment of patients with newly-diagnosed very low risk and low risk fusion negative rhabdomyosarcoma Currently recruiting
- Effects of Dexrazoxane Hydrochloride on biomarkers associated with cardiomyopathy and heart failure Currently recruiting
- STOP 360: Standardizing Treatments for Pulmonary Exacerbations: A platform for evaluating treatment decisions to improve outcomes Currently recruiting
- Recovery after ECMO in children with Acute Respiratory Distress Syndrome Currently recruiting
- TrialNet Pathway to Prevention of T1D Currently recruiting
- A Study to Assess Children with Hypochondroplasia Currently recruiting
- Medical device study for patients with a rare kidney disease (Focal Segmental Glomerulosclerosis) Currently recruiting
- Efficacy of KL1333 in adult patients with primary mitochondrial disease Currently recruiting
- North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) Currently recruiting
- Safety and efficacy of Rimegepant for the treatment of migraine in pediatric patients ≥6 to <18 years of age Currently recruiting
- Alpers Huttenlocher natural history study (Alpers) Currently recruiting
- Study of CAP-1002 in Ambulatory and Non-Ambulatory Patients With Duchenne Muscular Dystrophy Currently recruiting
- ROCK Prospective Cohort Study for Osteochondritis Dissecans of the Knee Currently recruiting
- Safety and efficacy of MACI in Patients with Chondral or Osteochondral Knee Defects (PEAK) Currently recruiting
- Prospective Database Registry of Scoliosis in Children with Cerebral Palsy Currently recruiting
- Study of Scoliosis Correction in patients with Marfan Syndrome Currently recruiting
- Prospective Database Registry of Scheuermann's Kyphosis Currently recruiting
- Scoliosis Outcomes Database Registry Currently recruiting
- Safety and Efficacy of Subdermal Betadine During Posterior Spinal Fusion Currently recruiting
- Pediatric Spine Registry Currently recruiting
- Implementation of a US/Canadian Diagnostic Registry of Children with Chronic Vasculitis Currently recruiting
- The CARRA Registry for Pediatric Rheumatic Diseases Currently recruiting
- Bracing vs casting in the treatment of idiopathic early-onset scoliosis Currently recruiting
- An assessment of clinical efficacy of hypothermic therapy following Pivotal Trial II (mTBI) in the adolescent athlete with concussion Currently recruiting

