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Trisomy Analysis (Chromosome 13, 18, 21) by DNA FISH, Newborn Smear

Cytogenetics Laboratory : Cytogenetics

Test ID/Workstation :
Specimen Type:
Blood, Bone Marrow
Tube Type:
Green top (sodium heparin) tube
Collection Volume:
0.5 mL
Cause for Rejection:
Clotted, non-sterile, or frozen specimen
Mon-Fri (0700-1600) Sat (0900-1300)
Smears are prepared and pretreated, hybridized overnight with appropriate DNA probe(s), washed, and counterstained. 100-300 cells are analyzed using a fluorescence microscope and images are captured digitally using image analysis software.
Special Instructions:
Typically in situ hybridization results are captured by standard cytogenetic studies. Include pertinent medical findings on the requisition with suspected diagnosis and/or indication(s) for testing.
6-36 hours for X, 4,18. Overnight-36 hours for 13 and 21
Additional Info:
Interpretation is provided with report Not orderable in Epic
CPT Code:
88271 (each probe), 88275, 88291
FISH; Fluorescent in situ hybridization
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