MTHFR DNA Panel

Molecular Diagnostics : DNA

PATIENT INFO

Patient Name:

Medical Record #:

BD: / / Sex: F M

PHYSICIAN INFO

Physician Name :

Address:

Ph: ( ) - Fax: ( ) -

Additional Report to:

Ph: ( ) - Fax: ( ) -

TESTS REQUESTED
Test Name:	ICD9 Code: (required)
1. MTHFR DNA Panel
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SPECIMEN INFO

Collection Date & Time:

Collected By:

Hospital:

Lab/Phone:

330-543-8722

Additional Info:

Discontinuation of Testing

Practice guidelines from the American College of Medical Genetics (ACMG)¹ and the American College of Obstetricians and Gynecologists ² state that MTHFR polymorphism genotyping should not be ordered for thrombophilia screening, recurrent pregnancy loss, or testing of family members of individuals with identified MTHFR variants. MTHFR genetic testing is also discouraged by Choosing Wisely recommendations from the Society for Maternal Fetal Medicine ³ and ACMG ⁴. There is no conclusive evidence supporting the clinical value of MTHFR genetic testing. No alternative tests are recommended.

References:

ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing. Genetics in Medicine 2013;15:153-156
ACOG Practice Bulletin Summary Obstetrics and Gynecology 2018;132:249-251
MTHFR mutations | Choosing Wisely
MTHFR genetic testing for hereditary thrombophilia | Choosing Wisely

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