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Multisystem Inflammatory Syndrome in Children Associated with COVID-19: A newly defined syndrome distinct from Kawasaki Disease

02-19-2021

By Scott Pangonis, MD , Associate Director, Infectious Disease, Akron Children's Hospital, Akron, OH

Infectious Disease

More about Scott Pangonis, MD, MS, FAAP


Objectives (Educational Content) :

1. Identify the clinical, laboratory and imaging findings of multisystem inflammatory syndrome in children associated with COVID (MIS-C). 2. Describe the proposed pathophysiology of MIS-C. 3. Compare and contrast MIS-C and Kawasaki Disease. 4. Explain the interim guidance algorithm developed to identify and manage patients with MIS-C at Akron Children's Hospital.

Target Audience:

General pediatricians, family physicians, nurse practitioners, physician assistants, social workers, psychologists and nurses

Identified Gap:

New information regarding differences between MIS-C and Kawasaki Disease.

Estimated Time to Complete the Educational Activity:

1 hour

Expiration Date for CME Credit:

02-18-2022

Method of Physician Participation in the Learning Process:

The learner will view the presentation, successfully complete a post-test and complete an activity evaluation.

Evaluation Methods:

All learners must successfully complete a post-test, as well as an activity evaluation, to claim CME credit.

Disclosure:

Dr. Pangonis has indicated that he has no relevant financial interest in any pharmaceutical or medical device company and that this activity was developed independent of commercial interest.

Accreditation Statement:

Children’s Hospital Medical Center of Akron is accredited by the Ohio State Medical Association to provide continuing medical education for physicians.

CHMCA designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit TM.  Physicians should only claim the credit commensurate with the extent of their participation in the activity. 

Bibliography:

1.Dufort EM, Koumans EH, Chow EJ, et al. Multisystem inflammatory syndrome in children in New York state. N Engl J Med. 2020;383(4):347-358. doi:10.1056/NEJMoa2021756

2.Jiang L, Tang K, Levin M, et al. COVID-19 and multisystem inflammatory syndrome in children and adolescents. Lancet Infect Dis. 2020;20(11):e276-e288. doi:10.1016/S1473-3099(20)30651-4

3.Carter MJ, Shankar-Hari M, TibbySM. Paediatric Inflammatory Multisystem Syndrome Temporally-Associated with SARS-CoV-2 Infection: An Overview. Intensive Care Med. 2021;47(1):90-93. doi:10.1007/s00134-020-06273-2

4.Henderson LA, Canna SW, Friedman KG, et al. American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS–CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 1. Arthritis Rheumatol. 2020;72(11):1791-1805. doi:10.1002/art.41454