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Grand Rounds: Management of Well-Appearing Febrile Infant 8 to 60 Days Old: AAP Guidelines and ACH Algorithms


By P. Rajbhandari, MD, Director, Pediatric Hospital Medicine Fellowship Program, and Scott Pangonis, MD, MS, FAAP, Associate Director, Infection Control, Akron Children's Hospital, Akron, OH , and Crista Cerrone, MD, Pediatric Specialist, Nationwide Children’s Hospital, Columbus, OH

Objectives (Educational Content) :

1. Identify the key recommendations on the management of well-appearing febrile infant 8-60 days old, as per the clinical guideline from AAP. 2. Integrate the shared framework for how to think about the diagnostic workup, risk stratification, and treatment of febrile infants. 3. Explain the modifications in the clinical practice guidelines for febrile infant management at Akron Children's Hospital based on the AAP recommendation.

Target Audience:

General pediatricians, family physicians, nurse practitioners, physician assistants, social workers, psychologists, and nurses.

Identified Gap:

Update on febrile infant management from the AAP.

Estimated Time to Complete the Educational Activity:

1 hour(s)

Expiration Date for CE/CME Credit:


Method of Participation in the Learning Process:

The learner will view the presentation, successfully complete a post-test and complete an activity evaluation.

Evaluation Methods:

All learners must successfully complete a post-test, as well as an activity evaluation, to claim CE/CME credit.


The speakers, Prabi Rajbhandari, MD, Scott Pangonis, MD and Crista Cerrone, MD have all indicated that there are no relevant financial or other relationships with any commercial interests and that this activity was developed independent of commercial interest.

Accreditation Statement:

Children’s Hospital Medical Center of Akron is accredited by the Ohio State Medical Association to provide continuing medical education for physicians.

CHMCA designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit TM.  Physicians should only claim the credit commensurate with the extent of their participation in the activity.


Robert H. Pantell, Kenneth B. Roberts, William G. Adams, Benard P. Dreyer, Nathan Kuppermann, Sean T. O’Leary, Kymika Okechukwu, Charles R. Woods; SUBCOMMITTEE ON FEBRILE INFANTS, Clinical Practice Guideline: Evaluation and Management of Well-Appearing Febrile Infants 8 to 60 Days Old. Pediatrics August 2021; 148 (2): e2021052228. 10.1542/peds.2021-052228

Mintegi S, Bressan S, Gomez B et al Accuracy of a sequential approach to identify young febrile infants at low risk for invasive bacterial infection. Emerg Med J. 2014;31(e1):e19–e24

Aronson PL, ShabanovaV, ShapiroED et al; Febrile Young Infant Research Collaborative. A Prediction model to identify febrile infants ≤60 days at low risk of invasive bacterial infection. Pediatrics. 2019;144(1):e20183604

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