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Grand Rounds: Updates in Pediatric Severe Asthma Treatment: From Bedside to Biologics


By Allyson S. Larkin, MD, FAAAAI , Associate Professor of Pediatrics, Division of Allergy and Immunology, UPMC Children’s Hospital of Pittsburgh

Objectives (Educational Content) :

1. Recognize the prevalence of severe asthma. 2. Explain the pathophysiology of the disease specifically related to inflammatory pathways. 3. Describe treatment options, specifically biologic therapies, and how they are chosen. 4. Assess side effect profiles of biologic therapies and how to monitor treatment.

Target Audience:

General pediatricians, family physicians, nurse practitioners, physician assistants, social workers, psychologists and nurses.

Identified Gap:

An update in treatment options such as biologic therapies, how they are selected and how they are monitored.

Estimated Time to Complete the Educational Activity:

1 hour

Expiration Date for CME Credit:


Method of Physician Participation in the Learning Process:

The learner will view the presentation, successfully complete a post-test and complete an activity evaluation.

Evaluation Methods:

All learners must successfully complete a post-test, as well as an activity evaluation, to claim CME credit.


Dr. Larkin has indicated the following affiliations/financial interests: PI: TATE Study (Astra Zeneca) Safety and Pharmacokinetics of Fasenra (Benralizumab) in Children age 6-11 .

Accreditation Statement:

Children’s Hospital Medical Center of Akron is accredited by the Ohio State Medical Association to provide continuing medical education for physicians.

CHMCA designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit ™. Physicians should only claim the credit commensurate with the extent of their participation in the activity.


Guilbert, TW, et al. J Allergy Clin Immunol Pract. 2014

Chung, K., et al. ERS/ATS Guidelines on Severe Asthma. 2014

Wenzel, SE. Asthma Phenotype: The Evolution from Clinical to Molecular Approaches. Nature Medicine. 2012

Anderson, W. et al. It’s Time to Start Phenotyping Our Patients with Severe Asthma. Immunol Allergy Clin N Am. 2019

GINA 2019 Global Strategy for Asthma Management and Prevention Update