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Grand Rounds: A Hundred Years of Insulin: We Have Come Far, but Challenges Continue


By Naveen Uli, MD , Director, Center for Diabetes and Endocrinology, Akron Children's Hospital, Akron, OH


More about Naveen Uli, MD

Objectives (Educational Content) :

1. Recognize the significant progress made with insulin preparations over the hundred years since the discovery of insulin. 2. Describe the innovations in insulin delivery and continuous glucose sensing systems that are assisting individuals with diabetes. 3. Identify the inequities and barriers to the use of advanced diabetes management technologies.

Target Audience:

General pediatricians, family physicians, nurse practitioners, physician assistants, social workers, psychologists, and nurses.

Identified Gap:

Update in methods of insulin delivery and advancements in continual glucose monitoring.

Estimated Time to Complete the Educational Activity:

1 hour(s)

Expiration Date for CE/CME Credit:


Method of Participation in the Learning Process:

The learner will view the presentation, successfully complete a post-test and complete an activity evaluation.

Evaluation Methods:

All learners must successfully complete a post-test, as well as an activity evaluation, to claim CE/CME credit.


Dr. Naveen Uli has indicated that there are no relevant financial or other relationships with any commercial interests and that this activity was developed independent of commercial interest.

Accreditation Statement:

Children’s Hospital Medical Center of Akron is accredited by the Ohio State Medical Association to provide continuing medical education for physicians.

CHMCA designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit TM.  Physicians should only claim the credit commensurate with the extent of their participation in the activity.


Fralick M, Zinman B. The discovery of insulin in Toronto: beginning a 100 year journey of research and clinical development. Diabetologia 2021; 64: 947-953

The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 339: 977-986

The Endocrine Society. Addressing insulin access and affordability: an Endocrine Society position statement. J Clin Endocrinol Metab 2021; 106 (4): 935-941