Division of Clinical Pharmacology and Toxicology

With knowledge of drug actions in living organisms, clinical pharmacologists seek to maximize a medication's therapeutic value while minimizing potential side effects. Akron Children's division of Clinical Pharmacology and Toxicology is available 24/7 for inpatient consultations to make prescribing recommendations based on a child's age, physical development, medical condition and history.

Although infants, children and adolescents differ widely from adults physically and mentally, most new drug therapies are proven safe and effective in clinical studies using adult subjects. As a result, pediatricians typically rely on a child's body weight to calculate an appropriate medication dose. Some 5 to 10 percent of children and teens, however, may not respond to the prescribed dose or suffer serious side effects. For those patients, Akron Children's clinicians frequently consult our division specialists for advice.

To contact our pharmacology & toxicology clinic, call 330-543-5011.

Clinical Toxicology

Clinical toxicologists diagnose and manage effects of poisonous or harmful substances that are hazardous to infants and children. The hospital staff calls on the division's clinicians for expert opinions on treating accidental child poisonings, toxic substance exposure, or severe alcohol and drug abuse reactions.

Lead Detoxification Program

Lead remains an important environmental containment harmful to the growing child. To provide integrated care and treatment for children with elevated blood lead concentrations, the division collaborated with Akron Children's Diagnostic Referral Group to establish the Lead Exposure and Detoxification (L.E.A.D.) Program.

Since high blood lead concentrations can produce developmental and behavioral health problems, a comprehensive team of pediatricians, clinical toxicologists, nutritionists, and social workers provide services on an inpatient and outpatient basis. In this manner, the L.E.A.D. program functions as a full-service regional resource to meet the special needs of children with harmful exposure to lead in the environment.

Pediatric Personalized Medicine (Pharmacogenomics)

Whether a medicine works well for you - or causes serious side effects - depends, to some extent, on your genes. Studying how an individual's genetic inheritance affects the body's response to drugs is called pharmacogenomics.
Akron Children's Clinical Pharmacology and Toxicology Division joined with our Genetic Center and Pathology and Laboratory Medicine to establish one of the nation's first outpatient clinics devoted to pediatric pharmacogenomics. This combination of expertise in genetics and pharmacology serves children and teens who fail to reasonably benefit from their medication or experience unexpected or severe side effects.

Also known as "personalized medicine," this rapidly advancing healthcare field is informed by each person's unique genomic and environmental information. Since these factors differ for every person, including how they respond to drugs, pharmacogenomics holds the promise that, one day, drugs will be customized for individuals based on each person's genetic makeup.

Research and Educational Programs

Collaborating with Akron Children’s Rebecca D. Considine Research Institute, the division’s staff conducts clinical studies to:

Our division is also dedicated to educating future clinicians, offering medical students an opportunity to gain experience in patient-centered pediatric pharmaco-therapy by completing a rotation at Akron Children’s Hospital. Additionally, the division provides education for pharmacy students and fellowships in pediatric clinical pharmacology and toxicology.

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