Aspergillus galactomannan Antigen
Centralized Core Laboratory:Chemistry
Gold top SST (serum separator tube, no anticoagulant)
4.0 mL(2.5 mL minimum)
Sent to reference laboratory
Enzyme Immunoassay (EIA)
Send specimen in original container. Do not Aliquot.
Two or more consecutive positive results should be obtained from separately drawn specimens before the patient is considered to have a positive Aspergillus antigen test. False positive results can be caused by: Piperacillin-tazobactam and a few other antibiotics; plasmalyte and other fluids containing sodium gluconate; Infection with Penicillium, Alternaria and Paecilomyces; Histoplasmosis, and possibly other endemic mycoses. The Platelia(r) Aspergillus EIA kit was evaluated for sensitivity (52.9% and 79.3%) and specificity (87.0% and 88.8%) in the multicenter US study that led to its FDA clearance of serum for pediatric and adult patients, respectively. The performance of this assay has not been evaluated with neonate samples. Antifungal therapy may reduce the assay's sensitivity.
Reference range: Aspergillus galactomannan Ag:
Range: <0.5 Index
Days Performed: Mon-Fri