Our bodies produce several kinds of wastes, including sweat, carbon dioxide gas, feces (stool), and urine (pee). These wastes exit the body in different ways. Sweat is released through pores in the skin. Water vapor and carbon dioxide are exhaled from the lungs. And undigested food materials are formed into feces in the intestines and excreted from the body as solid waste in bowel movements.
Urine, which is produced by the kidneys, contains the byproducts of metabolism — salts, toxins, and water — that end up in the blood. The kidneys and urinary tract (which includes the kidneys, ureters, bladder, and urethra) filter and eliminate these waste substances from our blood. Without the kidneys, waste products and toxins would soon build up in the blood to dangerous levels.
Besides eliminating wastes, the kidneys and urinary tract also regulate many important body functions. For example, the kidneys monitor and maintain the body's balance of water, ensuring that our tissues receive enough water to work properly and be healthy.
When doctors take a urine sample, the results reveal how well the kidneys are working. For example, blood, protein, or white blood cells in pee may indicate injury, inflammation, or infection of the kidneys, and glucose in the urine may be an indication of diabetes.
Although the two kidneys work together to perform many vital functions, people can live a normal, healthy life with just one kidney. In fact, some people are born with just one of these bean-shaped organs. If one kidney is removed, the remaining one will enlarge within a few months to take over the role of filtering blood on its own.
Every minute, more than 1 quart (about 1 liter) of blood goes to the kidneys. About one fifth of the blood pumped from the heart goes to the kidneys at any one time.
In addition to filtering blood, producing urine, and ensuring that body tissues receive enough water, the kidneys also regulate blood pressure and the level of vital salts in the blood. By regulating salt levels through production of an enzyme called renin (as well as other substances), the kidneys ensure that blood pressure is regulated.
The kidneys also secrete the hormone erythropoietin, which stimulates and controls red blood cell production (red blood cells carry oxygen throughout the body). In addition, the kidneys help regulate the acid-base balance (or the pH) of the blood and body fluids, which is necessary for the body to function normally.
The kidneys are located just under the ribcage in the back, one on each side. The right kidney is located below the liver, so it's a little lower than the left one. Each adult kidney is about the size of a fist. Each has an outer layer called the cortex, which contains the filtering units.
The center part of the kidney, the medulla, has 10 to 15 fan-shaped structures called pyramids. These drain urine into cup-shaped tubes called calyxes. A layer of fat surrounds the kidneys to cushion and help hold them in place.
Here's how the kidneys filter blood: Blood travels to each kidney through the renal artery, which enters the kidney at the hilus, the indentation in middle of the kidney that gives it its bean shape. As it enters the cortex, the artery branches to envelope the nephrons — 1 million tiny filtering units in each kidney that remove the harmful substances from the blood.
Each of the nephrons contain a filter called the glomerulus, which contains a network of tiny blood vessels known as capillaries. The fluid filtered from the blood by the glomerulus then travels down a tiny tube-like structure called a tubule, which adjusts the level of salts, water, and wastes that are excreted in the urine.
Filtered blood leaves the kidney through the renal vein and flows back to the heart.
The continuous blood supply entering and leaving the kidneys gives the kidneys their dark red color. While the blood is in the kidneys, water and some of the other blood components (such as acids, glucose, and other nutrients) are reabsorbed back into the bloodstream. Left behind is urine. Urine is a concentrated solution of waste material containing water, urea, a waste product that forms when proteins are broken down), salts, amino acids, byproducts of bile from the liver, ammonia, and any substances that cannot be reabsorbed into the blood. Urine also contains urochrome, a pigmented breakdown product of blood that gives urine its yellowish color.
The renal pelvis, located near the hilus, collects the urine flowing from the calyxes. From the renal pelvis, urine is transported out of the kidneys through the ureters, tubes that carry the urine out of each kidney to be stored in the urinary bladder — a muscular collection sac in the lower abdomen.
The bladder expands as it fills and can hold about 2 cups (half a liter) of urine at any given time (an average adult produces about 6 cups, or 1½ liters, of urine per day). An adult needs to produce and excrete at least one third of this amount in order to adequately clear waste products from the body. Producing too much or not enough urine may be a sign of illness.
When the bladder is full, nerve endings in its wall send impulses to the brain. When a person is ready to urinate, the bladder walls contract and the sphincter (a ring-like muscle that guards the exit from the bladder to the urethra) relaxes. The pee is ejected from the bladder and out of the body through the urethra, another tube-like structure. The male urethra ends at the tip of the penis; the female urethra ends just above the vaginal opening.
Like other systems in the body, the entire urinary tract is subject to diseases and disorders.
In kids, the more common problems include:
Congenital problems of the urinary tract. As a fetus develops in the womb, any part of the urinary tract can grow to an abnormal size or in an abnormal shape or position. One common congenital abnormality (an abnormality that exists at birth) is duplication of the ureters, in which a kidney has two ureters coming from it instead of one. This defect occurs in about 1 out of every 125 births and can cause the kidney to develop problems with repeated infections and scarring over time.
Another congenital problem is horseshoe kidney, where the two kidneys are fused (connected) into one arched kidney that usually functions normally, but is more prone to develop problems later in life. This condition is found in 1 out of every 500 births.
Glomerulonephritis is an inflammation of the glomeruli, the parts of the filtering units (nephrons) of the kidney that contain a network of capillaries (tiny blood vessels). The most common form is post-streptococcal glomerulonephritis, which usually occurs in young children following a case of strep throat. Most kids with this type of nephritis recover fully, but a few can have permanent kidney damage that eventually requires dialysis or a kidney transplant.
High blood pressure (or hypertension) can result when the kidneys are impaired by disease. The kidneys control blood pressure by regulating the amount of salt in the body. They also produce the enzyme renin that, along with other substances, controls the constriction of muscle cells in the walls of the blood vessels, which affects a person’s blood pressure.
Kidney (renal) failure can be acute (sudden) or chronic (happening over time and usually long lasting or permanent). In either form of kidney failure, the kidneys slow down or stop filtering blood effectively, causing waste products and toxic substances to build up in the blood.
Acute kidney failure may be due to many things, including a bacterial infection, injury, shock, heart failure, poisoning, or drug overdose. Treatment includes correcting the problem that led to the failure and sometimes requires surgery or dialysis. Dialysis involves using a machine or other artificial device to remove the excess salts and water and other wastes from the body when the kidneys are unable to perform this function.
Chronic kidney failure involves a deterioration of kidney function over time. In children, it can result from acute kidney failure that fails to improve, birth defects of the kidney, chronic kidney diseases, repeated kidney infections, or chronic severe high blood pressure. If diagnosed early, chronic kidney failure in children can be treated but usually not reversed. The child may require a kidney transplant at some point in the future.
Kidney stones (or nephrolithiasis) result from the buildup of crystallized salts and minerals such as calcium in the urinary tract. Stones (also called calculi) can also form after an infection. If kidney stones are large enough to block the kidney or ureter, they can cause severe abdominal pain. But the stones usually pass through the urinary tract on their own. In some cases, they may need to be removed surgically.
Nephritis is any inflammation of the kidney. It can be caused by infection, medications, an autoimmune disease (such as lupus), or it may be idiopathic (which means the exact cause may not be known or understood). Nephritis is generally detected by protein and blood in the urine.
Nephrotic syndrome is a type of kidney disease that leads to loss of protein in the urine and swelling of the face (often the eyes) or body (often around the genitals). It is most common in children younger than 6 years old and is more prevalent in boys. Nephrotic syndrome is often treated with steroids.
Urinary tract infections (UTIs) usually care aused by intestinal bacteria, such as E. coli, normally found in feces. These bacteria can cause infections anywhere in the urinary tract, including the kidneys. Most UTIs occur in the lower urinary tract, in the bladder and urethra. UTIs occur in both boys and girls. In school-age children, girls are more likely to develop UTIs than boys; this may be because girls have shorter urethras than boys.
Vesicoureteral reflux (VUR) is a condition in which urine abnormally flows backward (or refluxes) from the bladder into the ureters. It may even reach the kidneys, where infection and scarring can occur over time. VUR occurs in 1% of children and tends to run in families. It's often detected after a young child has a first urinary tract infection. Most kids outgrow mild forms of VUR, but some can develop permanent kidney damage and kidney failure later in life.
Wilms' tumor is the most common kidney cancer occurring in children. It is diagnosed most commonly between 2 and 5 years of age and affects males and females equally.
Reviewed by: Yamini Durani, MD
Date reviewed: May 2015
|National Institute of Diabetes and Digestive and Kidney Diseases This group conducts and supports research on many serious diseases affecting public health.|
|National Kidney Foundation (NKF) NKF seeks to prevent kidney and urinary tract diseases, improve the health and well-being of individuals and families affected by these diseases, and increase the availability of all organs for transplantation.|
|Nephron Information Center The Nephron Information Center offers information about how the kidneys work, transplants, and links to other sites.|
|American Association of Kidney Patients (AAKP) The AAKP serves kidney patients and their families by helping them cope with the emotional, physical, and social impact of kidney failure.|
|Lupus Foundation of America The mission of the Lupus Foundation of America is to educate and support those affected by lupus and find a cure. Call (800) 558-0121 for information.|
|Urinary Tract Infections A urinary tract infection (UTI) is one of the most common reasons that teens visit a doctor. Learn about the symptoms of UTIs, how they're treated, and more in this article.|
|Your Urinary System You pee every day, but what makes it happen? Find out in this article for kids about the urinary system.|
|Renal Tubular Acidosis This kidney problem causes acid levels in the blood to become too high, causing fatigue, muscle weakness, and other kidney problems. The condition is usually treatable.|
|Kidney Disease Sometimes, the kidneys aren't able to do their job properly. Other than kidney infections, the two most common kidney conditions among teens are nephritis and nephrosis.|
|Kidney Dialysis Dialysis is a medical treatment that can take over the job of filtering the blood until someone's failing kidneys heal or are replaced with a kidney transplant.|
|Ultrasound: Renal (Kidneys, Ureters, Bladder) A renal ultrasound makes images of your child's kidneys, ureters, and bladder. Doctors may order this test if they suspect kidney damage, cysts, tumors, kidney stones, or complications from urinary tract infections.|
|Urinary Tract Infections Urinary tract infections (UTIs) are common in kids, but often can be prevented. Early detection and treatment are key.|
|Recurrent Urinary Tract Infections and Related Conditions Recurrent urinary tract infections can cause kidney damage if left untreated, especially in kids under age 6. Here's how to recognize the symptom of UTIs and get help for your child.|
|Kidney Transplant If the kidneys stop working, a person will need either dialysis or a transplant. Get the facts on kidney transplant in this article for teens.|
|When Your Child Needs a Kidney Transplant If your child needs a kidney transplant, you're probably feeling lots of emotions. Fortunately, many kids who undergo kidney transplants go on to live normal, healthy lives.|
|Urinary Tract Infections (UTIs) You probably don't think much about urinating, or peeing. But what if it starts to sting? Find out more in this article for kids.|
|Chronic Kidney Diseases Kidneys are about the size of your fist and shaped like beans. What happens when this important pair of organs doesn't work well? Find out in this article for kids.|
|When Your Child Has a Chronic Kidney Disease Parents of kids who have a chronic kidney disease often worry about what might happen next, how their child feels, and what treatments are likely to be involved. Find answers here.|
|Kidney Diseases in Childhood The kidneys play a critical role in health. When something goes wrong, it could indicate a kidney disease. What are kidney diseases, and how can they be treated?|
|Glomerulonephritis With glomerulonephritis, tiny filtering units in the kidneys stop working properly, causing problems like too much fluid in the body and swelling. Most of the time it can be treated. Find out more.|
|Kidney Stones Kidney stones mostly happen to adults, but sometimes kids and teens can get them. Find out what kidney stones are, how to treat them, and ways to help prevent them.|
|Kidney Stones Kidney stones mostly happen to adults, but sometimes teens can get them. Find out what kidney stones are, how to treat them, and ways to help prevent them.|
|Vesicoureteral Reflux (VUR) This problem with the urinary tract causes urine to flow backward from the bladder to the kidneys. Most cases can be treated effectively, and many kids outgrow the condition.|
|Urine Tests Is your child having a urine culture or urinalysis performed? Find out why urine tests are performed, and what to expect when the doctor orders them.|
|Kidneys and Urinary Tract The kidneys perform several functions that are essential to health, the most important of which are to filter blood and produce urine.|
|Your Kidneys You need at least one kidney to live. Find out why in this article for kids.|
|Ultrasound: Bladder Doctors order bladder ultrasounds when there's a concern about bladder problems, such as difficulty urinating or daytime wetting.|
|Glomerulonephritis Glomerulonephritis happens when tiny filtering units in the kidneys stop working properly. Most cases get better on their own or with treatment.|
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