Lupus can be difficult to diagnose because it can affect almost any organ in the body and its symptoms — including joint pain, fatigue, muscle pain, rash, mouth ulcers, and hair loss — vary widely from patient to patient. That is one of the greatest challenges of treating the disease for both doctors and their patients.
Lupus is a rheumatic (having to do with the muscles, joints, and connective tissue) condition that affects 1.5 million people in the United States, including an estimated 10,000 children. Nearly 90% of those diagnosed with lupus are female.
Lupus is an autoimmune disease in which the immune system mistakenly works against the body's own tissues. A healthy immune system produces proteins called antibodies that normally protect the body against bacteria and viruses that cause infections.
But when someone has lupus, the immune system can't tell the difference between the body's healthy cells and bacteria and viruses, so the antibodies attack the body's healthy cells.
Although the cause of lupus is unknown, researchers think that many factors may trigger the disease.
Genetics might play a role. Some people may have a genetic predisposition to lupus that is then activated by an infection, certain medications, or extreme physical or emotional stress. The hormone estrogen also may play a role and could help explain why it's more common in females than males.
Lupus also occurs more frequently in African Americans, Asian Americans, Latinos, and Native Americans than in caucasians.
The three main types of lupus are:
The two rashes commonly associated with lupus are:
Other common symptoms:
Someone with four or more of these signs or symptoms is likely to have SLE. Most patients don't develop all of them. Before making a diagnosis, doctors perform a physical exam and take blood tests to rule out any other diseases.
In addition to those symptoms, patients with lupus often have fever, weakness, fatigue, or weight loss. They may experience muscle aches, loss of appetite, swollen glands, hair loss, or abdominal pain, which can be accompanied by nausea, diarrhea, and vomiting.
Sometimes the fingers, toes, nose, or ears will be particularly sensitive to cold and will turn blue and white in cold temperatures, a condition known as Raynaud's phenomenon.
There is no known cure for lupus, but the symptoms of the disease can be controlled. Often a patient with lupus has a health care team that includes specialists who can help treat the symptoms. That team may include:
Part of managing lupus is preventing flares — times when the disease gets worse. During a flare-up, a person with lupus may feel much more tired, sick, feverish, and achy than usual. Almost all lupus patients take medication to control inflammation and reduce the risk of flares.
Doctors frequently prescribe corticosteroids to control inflammation. These aren't the same steroids some athletes take. If a doctor prescribes one of these medications, the dosage and any side effects will be carefully monitored.
For day-to-day muscle and joint pain, patients can take acetaminophen or any of a variety of nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, ibuprofen, or naproxen.
Others take antimalarial drugs (medicines first developed to prevent and treat malaria that also have proved helpful with lupus). Antimalarial drugs often help treat skin rashes and joint pain, and help prevent coronary artery disease and the involvement of other organ systems in lupus.
Some children who also have kidney disease may require more aggressive treatment with immunosuppressive drugs, which lower the body's immune system responses.
In 2011, belimumab was approved by the U.S. Food and Drug Administration (FDA) for the treatment of lupus, especially for arthritis, rashes, and fatigue.
Though the course that lupus takes cannot be predicted, certain lifestyle changes may help minimize flare-ups. Some doctors advise patients to avoid too much sun exposure by wearing sunscreen and protective clothing when outside.
Regular exercise can help prevent fatigue and joint stiffness. A balanced diet and sufficient rest also are important for maintaining general health and well-being.
Kids and teens with lupus are prone to the usual childhood illnesses, such as a viral infection or diarrhea. However, a fever, rash, or mouth sore might indicate the beginning of a flare. As you and your child become more familiar with the disease, you may learn to recognize signs that a flare-up is around the corner.
Call the doctor immediately if any of these symptoms appear:
The outlook for lupus patients is constantly improving. Over the past few decades, better tools to diagnose and treat lupus have remarkably improved the lives of those who live with the disease.
Reviewed by: AnneMarie C. Brescia, MD
Date reviewed: September 2011
|U.S. Food and Drug Administration (FDA) The FDA is responsible for protecting the public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, medical devices, our nation's food supply, cosmetics, and products that emit radiation.|
|Lupus Alliance of America The Lupus Alliance of America supports those individuals, organizations and agencies that are involved in research to find a cure for lupus or to improve treatment of the disease.|
|National Institute of Arthritis and Musculoskeletal and Skin Diseases This Web site provides the latest information about the treatment and prevention of arthritis and musculoskeletal and skin diseases.|
|Arthritis Foundation The mission of this group is to support research to find the cure for and prevention of arthritis and to improve the quality of life for those affected by arthritis.|
|Lupus Foundation of America The mission of the Lupus Foundation of America is to educate and support those affected by lupus and find a cure. Call (800) 558-0121 for information.|
|Bones, Muscles, and Joints Without bones, muscles, and joints, we couldn't stand, walk, run, or even sit. The musculoskeletal system supports our bodies, protects our organs from injury, and enables movement.|
|Immune System The immune system, composed of special cells, proteins, tissues, and organs that protect against germs and microorganisms, is the body's defense against disease.|
|Lupus Lupus is a disease that affects the immune system. Learn how lupus is treated, signs and symptoms, how to support a friend who has it, and more.|
|Life With Lupus Some people have an autoimmune disorder called lupus. Find out more in this article for kids.|
|Living With Lupus Lupus is known as an autoimmune disease in which a person's immune system mistakenly works against the body's own tissues.|
|Lyme Disease Lyme disease can affect the skin, joints, nervous system, and other organ systems. If diagnosed quickly and treated with antibiotics, Lyme disease in kids is almost always treatable.|
|Juvenile Idiopathic Arthritis Juvenile idiopathic arthritis (also called juvenile rheumatoid arthritis) affects some 50,000 kids in the United States. Learn more.|
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