Lactate dehydrogenase (also called lactic acid dehydrogenase, or LDH) is an enzyme found in almost all body tissues. It plays an important role in cellular respiration, the process by which glucose (sugar) from food is converted into usable energy for our cells.
Although LDH is abundant in tissue cells, blood levels of the enzyme are normally low. However, when tissues are damaged by injury or disease, they release more LDH into the bloodstream. Conditions that can cause increased LDH in the blood include liver disease, heart attack, anemia, muscle trauma, bone fractures, cancers, and infections such as meningitis, encephalitis, and HIV.
Even though an LDH test is useful in diagnosing tissue damage, other tests are usually necessary to pinpoint the location of the damage. One such test is called the LDH isoenzymes test. LDH isoenzymes are five kinds of the LDH enzyme that are found in specific concentrations in different organs and tissues. By measuring the blood levels of these isoenzymes, doctors can get a better idea of the type, location, and severity of the cellular damage.
The LDH test is generally used to screen for tissue damage. This damage may be acute (as in the case of a traumatic injury) or chronic (due to a long-term condition such as liver disease or certain types of anemia). It also may be used to monitor progressive conditions, such as muscular dystrophy and HIV.
No special preparations are needed for this test. On the day of the test, having your child wear a T-shirt or short-sleeved shirt can make things easier for the technician drawing the blood.
A health professional will usually draw the blood from a vein. For an infant, the blood may be obtained by puncturing the heel with a small needle (lancet). If the blood is being drawn from a vein, the skin surface is cleaned with antiseptic, and an elastic band (tourniquet) is placed around the upper arm to apply pressure and cause the veins to swell with blood. A needle is inserted into a vein (usually in the arm inside of the elbow or on the back of the hand) and blood is withdrawn and collected in a vial or syringe.
After the procedure, the elastic band is removed. Once the blood has been collected, the needle is removed and the area is covered with cotton or a bandage to stop the bleeding. Collecting the blood for the test will only take a few minutes.
Either method (heel or vein withdrawal) of collecting a sample of blood is only temporarily uncomfortable and can feel like a quick pinprick. Afterward, there may be some mild bruising, which should go away in a day or so.
The blood sample will be processed by a machine. The results are commonly available within a day or two.
The LDH test is considered a safe procedure. However, as with many medical tests, some problems can occur with having blood drawn, like:
Having a blood test is relatively painless. Still, many children are afraid of needles. Explaining the test in terms your child can understand might help ease some of the fear.
Allow your child to ask the technician any questions he or she might have. Tell your child to try to relax and stay still during the procedure, as tensing muscles and moving can make it harder and more painful to draw blood. It also may help for your child to look away when the needle is being inserted into the skin.
If you have questions about the LDH test, speak with your doctor.
Reviewed by: Yamini Durani, MD
Date reviewed: August 2014
|American Medical Association (AMA) The AMA has made a commitment to medicine by making doctors more accessible to their patients. Contact the AMA at: American Medical Association|
515 N. State St.
Chicago, IL 60610
|American Academy of Pediatrics (AAP) The AAP is committed to the health and well-being of infants, adolescents, and young adults. The website offers news articles and tips on health for families.|
|American Society of Hematology This group provides information relating to blood, blood-forming tissues, and blood diseases.|
|Blood Test (Video) These videos show what's involved in getting a blood test and what it's like to be the person taking the blood sample.|
|HIV and AIDS Parents who are well informed about how to prevent HIV and who talk with their kids regularly about healthy behaviors, feelings, and sexuality play an important part in HIV/AIDS prevention.|
|Encephalitis Encephalitis is a rare brain inflammation caused by a virus. The best way to avoid encephalitis is to prevent the illnesses that may lead to it.|
|Getting a Blood Test (Video) A blood test might sound scary, but it usually takes less than a minute. Watch what happens in this video for kids.|
|Anemia Anemia, one of the more common blood disorders, occurs when the number of healthy red blood cells decreases. This can result in a variety of symptoms, including fatigue and stress on all the body's organs.|
|Broken Bones, Sprains, and Strains Broken bones and torn muscles, ligaments, and tendons happen. Find out what to do if your child experiences any breaks, strains, or sprains.|
|Meningitis Meningitis (inflammation of the membranes that cover the brain and spinal cord) is treatable, but can be serious. So it's important to know the symptoms and get prompt diagnosis and treatment.|
|Broken Bones Although many kids will have one at some point, a broken bone can be scary for them and parents alike. To help make things a little easier if a spill results in a fracture, here's the lowdown on what to expect.|
|Bones, Muscles, and Joints Without bones, muscles, and joints, we couldn't stand, walk, run, or even sit. The musculoskeletal system supports our bodies, protects our organs from injury, and enables movement.|
What to expect when coming to Akron Children's
For healthcare providers and nurses
Residency & Fellowships, Medical Students, Nursing and Allied Health
For prospective employees and career-seekers
Our online community that provides inspirational stories and helpful information.