Tetanus, also known as lockjaw, is a serious but preventable disease that affects the body's muscles and nerves. It typically arises from a skin wound that becomes contaminated by a bacterium called Clostridium tetani, which is often found in soil.
Once the bacteria are in the body, they produce a neurotoxin (a protein that acts as a poison to the body's nervous system) that causes muscle spasms. The toxin can travel throughout the body via the bloodstream and lymph system. As it circulates more widely, the toxin interferes with the normal activity of nerves throughout the body, leading to generalized muscle spasms. Spasms can be so forceful that they tear muscles or even cause spine fractures. Without treatment, tetanus can be fatal.
In the United States, most cases of tetanus follow a contaminated cut or deep puncture injury, such as a wound caused by stepping on a nail. Sometimes the injury is so small the person never even sees a doctor. Injuries that involve dead skin (such as burns, frostbite, gangrene, or crush injuries) are more likely to cause tetanus. Wounds contaminated with soil, saliva, or feces — especially if not properly cleaned — and skin punctures from nonsterile needles (such as with drug use or self-performed tattooing or body piercing) are also at increased risk.
Another form of tetanus, neonatal tetanus, occurs in newborns who are delivered in unsanitary conditions, especially if the umbilical cord stump becomes contaminated. Prior to immunizations, neonatal tetanus was much more common in the United States. Now, routine immunizations for tetanus produce antibodies that mothers pass to their unborn babies. These maternal antibodies and sanitary cord-care techniques have made newborn tetanus very rare in developed countries.
In fact, tetanus in general is rare in the United States and other nations with tetanus vaccination programs — fewer than 50 cases of tetanus are reported each year in the United States. However, many developing countries have less effective prevention and immunization programs against tetanus, so the disease is much more common there.
Tetanus often begins with muscle spasms in the jaw (called trismus), and can be accompanied by difficulty swallowing and stiffness or pain in the muscles of the neck, shoulders, or back. These spasms can spread to the muscles of the abdomen, upper arms, and thighs. The symptoms can occur anywhere from days to months after exposure to the bacteria.
There are two important ways to prevent tetanus:
Tetanus immunization is part of the DTaP (diphtheria, tetanus, and acellular pertussis) vaccinations. Kids usually receive a series of four doses of DTaP vaccine before 2 years of age, followed by a booster dose at 4 to 6 years of age. After that, a booster (Tdap) is recommended at 11 to 12 years of age, or later if it was missed, followed by a tetanus and diphtheria booster every 10 years through adulthood. The Tdap vaccine is also recommended for all pregnant women during the second half of each pregnancy, regardless of whether or not they had the vaccine before, or when it was last given.
Neonatal tetanus can be prevented by making sure that all pregnant women have had their tetanus immunizations, by delivering babies in sanitary conditions, and by proper umbilical cord care. If you are pregnant, discuss your immunization record with your obstetrician well before your due date.
And be sure your kids don't miss their appointments so that the immunizations are given on time. As with all immunization schedules, there are important exceptions and special circumstances. Your doctor will have the most current information.
Post-exposure tetanus prophylaxis also involves getting tetanus shots, but after an injury occurs. Shots given will depend on the number of years since the patient's last booster, the total number of tetanus vaccinations the patient has received, and the nature of the wound. The doctor may recommend a tetanus booster (Td , DTaP, or Tdap, depending on the patient's age and previous immunizations) and/or an injection of tetanus immune globulin (TIG) to neutralize any toxin released by the bacteria.
Any skin wound — especially a deep puncture or a wound that may be contaminated with feces, soil, or saliva — should be cleaned and dressed right away. Although it's important to clean all wounds, remember that cleaning is not a substitute for immunization.
Doctors play an important role in preventing tetanus by making sure kids' immunizations are up to date and providing post-exposure prophylaxis if a child has a wound that's at risk for tetanus.
A child who does develop tetanus will be treated in a hospital, usually in the intensive care unit (ICU). There, a child typically receives antibiotics to kill bacteria and TIG to neutralize the toxin that the bacteria have already released. The child will also receive medicines to control muscle spasms and may be given treatment to support vital body functions.
If you're not sure whether your kids have been immunized against tetanus, or if you know they're not fully immunized, call your doctor. If it's been more than 10 years since someone in your family has had a tetanus booster, schedule an office visit to bring immunizations up to date.
If the event of a puncture or other deep wound, clean the wound and call the doctor to discuss whether your child should receive post-exposure tetanus prophylaxis. If your child develops lockjaw or muscle spasms — particularly after sustaining a wound — seek medical attention right away.
Reviewed by: Elana Pearl Ben-Joseph, MD
Date reviewed: February 2014
|Centers for Disease Control and Prevention (CDC) The CDC (the national public health institute of the United States) promotes health and quality of life by preventing and controlling disease, injury, and disability.|
|CDC: Vaccines & Immunizations The CDC's site has information on vaccines, including immunization schedules, recommendations, FAQs, and more.|
|Immunization Action Coalition This organization is a source of childhood, adolescent, and adult immunization information as well as hepatitis B educational materials.|
|Osteomyelitis Osteomyelitis is a bone infection caused by germs entering the body's tissues through an open wound. The easiest way to prevent it is to practice good hygiene.|
|Osteomyelitis Sometimes a bad cut that gets infected can lead to even worse things, like a bone infection called osteomyelitis. The easiest way to protect yourself is to practice good hygiene.|
|Wound Healing and Care How well a wound heals depends on where it is on the body and what caused it – as well as how well someone cares for the wound at home. Find out what to do in this article for teens.|
|Dealing With Cuts and Wounds Most cuts can be safely treated at home, but deep cuts and certain other injuries require medical treatment. Find out what to do by reading this printable instruction sheet.|
|Dealing With Cuts Find out how to handle minor cuts at home - and when to seek professional treatment.|
|A Kid's Guide to Shots If you're old enough to read this, you've probably had most of your shots. But even bigger kids may need a shot once in a while. Find out more about them in this article for kids.|
|Bites and Scratches Animal bites and scratches, even minor ones, can become infected and spread bacteria to other parts of the body, regardless of whether the animal is a family pet or a wild animal.|
|5 Tips for Surviving Shots If you're afraid of shots, you're not alone. Next time your doc asks you to roll up your sleeve, try these tips.|
|Tetanus Tetanus occurs when a certain type of bacterial infection grows in a contaminated wound. Because it can be serious, it's important to get immunized. Find out about tetanus and how to protect yourself against it.|
|Why Did I Feel Like Throwing Up After Stepping on a Nail? Find out what the experts have to say.|
|Your Child's Immunizations Immunizations protect your child from potentially fatal diseases. Find out what vaccines your child needs to grow up healthy.|
|Checking Out Cuts, Scratches, and Abrasions If you're wearing a bandage right now, chances are you have a cut, scratch, or abrasion. Find out more about them in this article for kids.|
|Frequently Asked Questions About Immunizations Immunizations have protected millions of children from potentially deadly diseases. Learn about immunizations and find out exactly what they do - and what they don't.|
What to expect when coming to Akron Children's
For healthcare providers and nurses
Residency & Fellowships, Medical Students, Nursing and Allied Health
For prospective employees and career-seekers
Our online community that provides inspirational stories and helpful information.